creos xenogain

A comprehensive range of xenogenic bone graft materials

creos bone graft solutions

creos xenogain comprehensive range

The creos xenogain portfolio comprises an extensive range of non-sintered xenogenic bone substitutes for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. 

The comprehensive range includes:

  • creos xenogain – deproteinized bovine bone mineral matrix with preserved micro- and macrostructures.1,2
  • creos xenogain collagen – a composite of creos xenogain and 10% porcine collagen type 1.

Why creos xenogain?

Easy handling

For quick and easy application of the graft, creos xenogain bone substitutes are delivered sterile and come either in a vial, in a syringe or in a bowl ready for mixing. Two granule sizes and up to four volume options offer a wide variety of alternatives.

Treat your patients with confidence

creos xenogain is biocompatible.3,4,5,6 Unique processing methods remove the bovine proteins and lipids.1,2 With a calcium phosphate ratio that reflects the composition in human bone and a low crystalline structure, creos xenogain is accepted by the body as a suitable framework for bone formation.2,7,8

The scaffold for successful regeneration

creos xenogain is characterized by a preserved natural bone matrix with micro- and interconnected macropore structures.1,2 It offers a suitable environment for new bone formation.2,3,4 creos xenogain promotes rapid hydration (capable to absorb 1.75x its weight of water mass in a few seconds).1

A solid foundation for implant treatment

creos xenogain acts as a slowly resorbing scaffold and maintains space for bone regeneration.4 The graft integrates with the newly formed bone, building a basis for successful implant placement.

creos xenogain collagen

A composite of creos xenogain and 10% porcine collagen type 1 for easy graft application e.g. in extraction sockets, that is available as a block or a syringe.

creos xenoprotect

Once the bone substitute is applied, the resorbable creos xenoprotect membrane can be used to hold it in place and act as a barrier to soft tissue ingrowth. 

Learn more


Dr. Bastian Wessing, Germany – Gap augmentation during immediate implant placement with immediate restoration

Situation: Hopeless tooth 11 after traumatic accident with discoloring, persistent pain and mobility grad II.

Solution: Immediate implant placement with gap augmentation using creos xenogain (small granules).

View case (PDF, 476 kB)

Dr. Sascha Jovanovic, USA – GBR procedure with simultaneous implant placement

Situation: Missing tooth #12 with post extraction bony defect in coronal part of the ridge.

Solution: Delayed implant placement (NobelActive 3.0 x 13 mm) in combination with a GBR procedure (using creos xenogain and creos xenoprotect).

Dr. med. dent. Annette Felderhoff-Fischer, Germany – Maxillary sinus floor elevation with simultaneous implant placement

Situation: Missing teeth #15 and 16, with inadequate bone height for the implant placement due to maxillary sinus pneumatization.

Solution: Maxillary sinus floor elevation (using creos xenogain and creos xenoprotect) in combination with immediate implant placement (NobelParallel CC Ø 5.0 x 10 mm at 15 and NobelParallel CC Ø 5.0 x 10 mm at 16).

Dr. Pedro Santos Silva, Portugal – Ridge augmentation and implant placement to enhance esthetic in implant dentistry

Situation: Missing central incisor due to trauma in childhood. Patient is under orthodontic treatment.

Solution: Implant placement (NobelActive 3.5 x 13 mm) with simultaneous bone augmentation using creos xenoprotect and creos xenogain (small granules 0.2 - 1.0 mm).

View case (PDF, 1 MB)

Dr. Ferdinando D'Avenia, Italy – Immediate implant placement in a site with severe buccal dehiscence

Situation: Chronic periodontitis. Tooth # 25 with porcelain fused to metal crown and metal post and core. Vertical root fracture occurred two months earlier. 10 mm “U” shaped buccal dehiscence.

Solution: Immediate implant placement (NobelParallel CC RP 4.3 x 13 mm) in combination with a GBR procedure (using creos xenogain and creos xenoprotect).


Dr. Bastian Wessing, Germany

Dr. Bastian Wessing, Germany

“What impressed me about this product was the variety of sizes and dosage forms, each offering very good handling properties.”

Univ.-Prof. DDr. Werner Zechner, Austria

Univ.-Prof. DDr. Werner Zechner, Austria

"After using the non-sintered creos xenogain bone substitute, I appreciated its handling properties and I see its high hydrophilicity as a biological advantage in peri-implant defect regeneration and sinus grafting."

Dr. Ferdinando D'Avenia, Italy

“creos xenogain is a user-friendly bone grafting material: hydration, manipulation and positioning is simplified by its wettability coupled with a smart syringe packaging that really makes things easy.” 

Dr. Pedro Santos Silva, Portugal

“What most impressed me about this product was the handling property and the fast integration.” 



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1 Data on file NIBEC

Data on file Nobel Biocare Material properties of CXG / biomaterials

Park H-N, et al. A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335–43

4 Park J-B, et al. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material(OCS-B). Clinical and histologic findings in human. The Journal of the Korean Dental Association. 2007;45(8):491–99

5 Shin S-Y, et al. Long-term results of new deproteinized bovine bone material in a maxillary sinus graft procedure. J Periodontal Implant Sci. 2014;44:259–64

View on Pubmed

6 Data on file NIBEC Biocompatibility tests: OCS-B and OCS-B Collagen

7 Kyriazis V, Tzaphlidou M. Skeletal Calcium/Phosphorus Ratio Measuring Techniques and Results. I. Microscopy and Microtomography. The Scientific World Journal. 2004;4:1027–34

View on Pubmed

8 Data on file NIBEC Atomic emission spectrometry analysis

Data on file NIBEC Porosity Analysis (BET measurement)